Indication:
Adalimumab generic Humira is a prescription medicine used to treat of various chronic inflammatory and autoimmune conditions, including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, Crohn’s disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and non-infectious uveitis in both adult and pediatric patients.
You can take this medicine if:
Adalimumab is a fully human monoclonal antibody that targets tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine involved in the pathogenesis of numerous autoimmune and inflammatory disorders. It is primarily indicated for the treatment of moderate to severe rheumatoid arthritis in adults, often in combination with methotrexate or as monotherapy in patients intolerant to conventional disease-modifying antirheumatic drugs (DMARDs). Adalimumab is also approved for juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), and plaque psoriasis, where it helps reduce inflammation, control symptoms, and slow disease progression by neutralizing TNF-α activity.
Additionally, Adalimumab is indicated for several gastrointestinal and dermatological conditions, including moderate to severe Crohn’s disease and ulcerative colitis in patients who have had an inadequate response to conventional therapy, as well as hidradenitis suppurativa and non-infectious uveitis. Its broad spectrum of indications reflects its targeted mechanism of action and robust anti-inflammatory effects. However, due to its immunosuppressive nature, treatment with Adalimumab requires careful screening for latent infections (such as tuberculosis), monitoring for adverse effects, and ongoing risk-benefit assessment, particularly in long-term use or in pediatric and elderly populations.
Dosage:
The dosage of Adalimumab varies depending on the specific indication, patient age, and clinical response, but the most common adult dosing for rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis is 40 mg administered subcutaneously every other week. For conditions such as plaque psoriasis, Crohn’s disease, and ulcerative colitis, an initial loading dose (e.g., 160 mg on day 1, followed by 80 mg on day 15) may be required, followed by a maintenance dose of 40 mg every other week. In pediatric patients, dosing is weight-based and condition-specific. Adalimumab is administered via prefilled syringe or autoinjector and should be injected into the thigh or abdomen, rotating sites with each dose.
Note:
As a tumor necrosis factor (TNF) inhibitor, Adalimumab suppresses the immune system and carries a black box warning for serious infections (such as tuberculosis and opportunistic infections) and malignancies, particularly in pediatric populations. Prior to initiating therapy, patients must be screened for latent TB and hepatitis B, and routine monitoring for infection, demyelinating disease, and blood abnormalities is essential throughout treatment. Patients should also be educated on proper injection techniques, storage (refrigeration required), and early signs of infection or hypersensitivity reactions.
Side Effect:
The most common adverse reactions of Adalimumab are:
Injection site reactions (redness, swelling, itching), Upper respiratory infections, Headache, Rash, Nausea.
The above information comes from the Internet. Please consult with a doctor for medical advice.
FAQ:
FAQ about (ADALIMUMAB)/ HUMIRA Generic ADALIMUMAB:
Q. Is (ADALIMUMAB)/ HUMIRA Generic ADALIMUMAB available to supply worldwide?
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ADALIMUMAB has different brand names depending on the manufacturer. Some of the brand names are: