Indication:

Idelalisib generic ZYDELIG is a prescription medicine used to treat of patients with relapsed chronic lymphocytic leukemia (CLL) in combination with rituximab, particularly in those for whom rituximab monotherapy is considered appropriate due to the presence of comorbid conditions. Idelalisib is used in the management of small lymphocytic lymphoma (SLL), follicular lymphoma (FL), and other indolent non-Hodgkin lymphomas.

You can take this medicine if:

Idelalisib is an oral selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor indicated for the treatment of certain hematologic malignancies. It is primarily used in the management of relapsed chronic lymphocytic leukemia (CLL), in combination with rituximab in patients for whom rituximab alone would be considered appropriate due to comorbidities. Idelalisib is also indicated for the treatment of relapsed follicular B-cell non-Hodgkin lymphoma (FL) and relapsed small lymphocytic lymphoma (SLL) in patients who have received at least two prior systemic therapies. By inhibiting the PI3Kδ isoform, which is predominantly expressed in leukocytes, idelalisib disrupts key signaling pathways involved in the survival, proliferation, and homing of malignant B cells.

Its targeted mechanism offers a therapeutic option for patients with refractory disease or those who are unsuitable for traditional chemotherapy. However, the clinical use of idelalisib requires careful consideration due to its associated serious adverse effects, including hepatotoxicity, severe diarrhea/colitis, pneumonitis, and intestinal perforation. Due to these risks, its use is typically reserved for patients with limited treatment alternatives or those who have not responded to previous therapies. Regular monitoring of liver function, gastrointestinal symptoms, and respiratory status is essential during treatment. As with other targeted therapies, treatment decisions involving idelalisib should be based on a thorough evaluation of the benefit-risk profile for each individual patient.

Dosage:

Idelalisib has to take orally twice daily with or without food as directed by patient’s doctor.

The recommended dosage of Idelalisib for adult patients is 150 mg taken orally twice daily, with or without food, until disease progression or unacceptable toxicity occurs. The tablets should be swallowed whole and not crushed, chewed, or broken. This dosing regimen is used for the treatment of relapsed chronic lymphocytic leukemia (CLL) in combination with rituximab, as well as for relapsed follicular lymphoma (FL) and small lymphocytic lymphoma (SLL) in patients who have received at least two prior systemic therapies. Dose modifications may be necessary based on the severity of adverse events, particularly hepatotoxicity, severe diarrhea or colitis, pneumonitis, or neutropenia, which require close monitoring and appropriate intervention, including temporary interruption, dose reduction, or permanent discontinuation.

Side Effect:

The most common adverse reactions of Idelalisib are:

Diarrhea​, Fever​, Fatigue​, Nausea​, Cough​, Pneumonia​, Abdominal pain​, Chills​, Rash​, Joint pain​, Night sweats​, Decreased appetite​, Increased thirst​, Heartburn​, MedlinePlus, Mayo Clinic, Difficulty sleeping​

The above information comes from the Internet. Please consult with a doctor for medical advice.

FAQ:

FAQ about (IDELALISIB)/ ZYDELIG Generic IDELALISIB:

Q. Is (IDELALISIB)/ ZYDELIG Generic IDELALISIB available to supply worldwide?

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IDELALISIB has different brand names depending on the manufacturer. Some of the brand names are: