Indication:
Paracetamol & Tramadol Hydrochloride generic Ultracet is a prescription medicine used to treat of acute pain conditions, including postoperative pain, musculoskeletal discomfort, and other clinical scenarios where a combination analgesic approach is deemed effective and appropriate.
You can take this medicine if:
Paracetamol and Tramadol Hydrochloride is a combination medication primarily indicated for the management of moderate to moderately severe pain when treatment with either agent alone is insufficient. Tramadol is a centrally acting synthetic opioid analgesic that binds to μ-opioid receptors and also inhibits the reuptake of norepinephrine and serotonin, thereby enhancing its analgesic effects. Paracetamol (acetaminophen), on the other hand, acts as a non-opioid analgesic and antipyretic, believed to exert its effects through central inhibition of prostaglandin synthesis. When combined, the two agents provide synergistic pain relief, offering both opioid and non-opioid mechanisms, which allows for effective analgesia with potentially lower individual doses and reduced risk of side effects.
This combination is commonly used in conditions such as musculoskeletal pain, postoperative pain, osteoarthritis, and neuropathic pain, where a multimodal approach to pain management is beneficial. It is typically administered orally and available in fixed-dose formulations, allowing for ease of dosing and compliance. However, caution is advised due to the risk of opioid-related adverse effects such as sedation, dependence, and respiratory depression from tramadol, as well as potential hepatotoxicity from paracetamol when used in excessive doses. Clinical use should be individualized, closely monitored, and limited to the shortest duration necessary to minimize risk while effectively controlling pain.
Dosage:
Paracetamol & Tramadol Hydrochloride has to take orally once daily with food or after meals.
The typical dosage of Paracetamol and Tramadol Hydrochloride combination for adults is one tablet containing 37.5 mg of tramadol hydrochloride and 325 mg of paracetamol, taken every 4 to 6 hours as needed for pain relief, with a maximum daily dose not exceeding 8 tablets (equivalent to 300 mg of tramadol and 2600 mg of paracetamol). This combination is intended for short-term use in managing moderate to moderately severe pain when monotherapy is inadequate. The dosage should always be tailored to the patient’s pain severity, response to therapy, and overall clinical condition, with adjustments made cautiously in elderly patients or those with hepatic or renal impairment.
Note:
Prolonged use of tramadol may lead to dependence, tolerance, and withdrawal symptoms, and its serotonergic properties may increase the risk of serotonin syndrome, especially when combined with other serotonergic agents. Additionally, excessive intake of paracetamol can result in severe hepatotoxicity, which may be fatal; thus, patients should be advised not to use other paracetamol-containing products concurrently. The combination is not recommended for pediatric use and should be prescribed with caution in patients with a history of substance abuse, seizure disorders, or respiratory depression.
Side Effect:
The most common adverse reactions of Paracetamol & Tramadol Hydrochloride are:
Nausea, Drowsiness or insomnia, Dry mouth, Dizziness, Headache, Loss of appetite, Sweating, Constipation or diarrhea, Sexual dysfunction.
The above information comes from the Internet. Please consult with a doctor for medical advice.
FAQ:
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PARACETAMOL & TRAMADOL HYDROCHLORIDE has different brand names depending on the manufacturer. Some of the brand names are: