Indication:
Quizartinib, generic Vanflyta is a prescription medicine used to treat treatment of newly diagnosed acute myeloid leukemia (AML) in adult patients with a confirmed FLT3 internal tandem duplication (ITD)-positive mutation. Quizartinib is utilized as part of a combination regimen with standard chemotherapy and as maintenance monotherapy following the completion of chemotherapy.
You can take this medicine if:
Acute myeloid leukemia (AML) is a rapidly progressing cancer of the blood and bone marrow, marked by the overproduction of immature white blood cells. In some patients, the cancer cells carry a specific genetic alteration known as the FLT3-ITD mutation, which causes continuous activation of the FLT3 protein—a receptor tyrosine kinase that promotes cell growth and survival.
The presence of this mutation can lead to more aggressive disease progression and a poorer prognosis. Quizartinib targets this mutation, helping to slow or halt the growth of these abnormal cells.
Quizartinib is a selective FLT3 inhibitor. By blocking the abnormal FLT3 signaling caused by the internal tandem duplication, the medication interferes with the leukemia cells’ ability to grow and divide. This targeted approach aims to reduce the number of cancerous cells and help restore healthy blood cell production in the bone marrow.
Dosage:
What is the dosage of Quizartinib?
Quizartinib has to take orally once a daily with or without food as directed by patients doctor.
Quizartinib can prolong the QT interval, leading to torsades de pointes and cardiac arrest. Use with caution in patients with a history of arrhythmias or those at risk for QT prolongation. Avoid concomitant use with strong or moderate CYP3A inducers, as they may decrease quizartinib exposure and efficacy. Vanflyta is available only through a restricted Risk Evaluation and Mitigation Strategy (REMS) program due to the risk of QT prolongation.
Side Effect:
What is the most common adverse reactions/ side effects of Quizartinib?
The most common side effects of Quizartinib are:
Nausea, vomiting, diarrhea, abdominal pain, mouth sores, decreased appetite, headache, or trouble sleeping.
The above information comes from the Internet. Please consult with doctor for medical advice.
FAQ about (QUIZARTINIB)/ VANFLYTA Generic QUIZARTINIB:
Q. Is (QUIZARTINIB)/ VANFLYTA Generic QUIZARTINIB available to supply worldwide?
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QUIZARTINIB has different brand names depending on the manufacturer. Some of the brand names are:
