Indication:

Ursodeoxycholic Acid generic Actigall is a prescription medicine used to treat of cholestasis (jaundice), primary biliary cirrhosis (PBC), non-alcoholic steatohepatitis (NASH), viral hepatitis, alcoholic fatty liver disease, primary sclerosing cholangitis (PSC), and the dissolution of cholesterol gallstones. UDCA is a naturally occurring hydrophilic bile acid derived from cholesterol and constitutes a minor component of the human bile acid pool. Oral administration increases its proportion in bile in a dose-dependent manner, allowing it to displace toxic, hydrophobic bile acids that accumulate in cholestatic liver diseases.

You can take this medicine if:

Ursodeoxycholic Acid (UDCA) is primarily indicated for the treatment of primary biliary cholangitis (PBC), a chronic autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts, where it serves as the first-line therapy to improve liver biochemistry and delay disease progression. It is also approved for the dissolution of radiolucent cholesterol gallstones in patients with a functioning gallbladder who are not suitable for surgery. In addition, UDCA is used off-label in a range of cholestatic and hepatobiliary conditions, including primary sclerosing cholangitis (PSC), intrahepatic cholestasis of pregnancy (ICP), non-alcoholic steatohepatitis (NASH), alcoholic fatty liver disease, and certain pediatric cholestatic disorders. Its mechanism of action involves replacing toxic, hydrophobic bile acids with its more hydrophilic form, thereby reducing bile acid–induced hepatocellular injury and promoting bile flow. Clinical response and liver function should be regularly monitored, especially in long-term therapy or in off-label indications, which should be managed under specialist supervision.

Dosage:

Ursodeoxycholic acid has to take orally 13-15 mg/kg/day in 2-4 divided doses for Primary Biliary Cirrhosis, 13-15 mg/kg/day for Non-Alcoholic Steato Hepatitis, 10-15 mg/kg/day for Acute Viral Hepatitis,15 mg/kg/day for Alcoholic Fatty Liver, 25-30 mg/kg/day for Primary Sclerosing Cholangitis, 8-12 mg/kg/day for Dissolution of Gallstones. Either as single night time dose or in divided doses.

The recommended dosage of Ursodeoxycholic Acid (UDCA) varies depending on the indication and patient body weight, with standard dosing ranging from 8 to 15 mg/kg/day. For primary biliary cholangitis (PBC), the most common approved indication, the typical dosage is 13–15 mg/kg/day, administered once daily or in two to three divided doses. In the treatment of cholesterol gallstones, a lower dose of 8–10 mg/kg/day is used, typically over a period of 6 months to 2 years, depending on stone size and composition. Off-label, UDCA is also employed in conditions such as intrahepatic cholestasis of pregnancy, primary sclerosing cholangitis (PSC), and non-alcoholic steatohepatitis (NASH) at similar dose ranges, though clinical evidence varies and specialist supervision is advised. The drug is available in capsule, tablet, and oral suspension forms, and is best taken with food to enhance bile flow and absorption. Liver function tests (ALT, AST, ALP, bilirubin) should be monitored regularly during treatment, and caution is warranted in patients with advanced liver disease or biliary obstruction.

Side Effect:

The most common adverse reactions of Ursodeoxycholic Acid are:

Upset stomach or stomach pain, Diarrhea or constipation, Nausea, Dizziness, Infection in the nose or throat, sore throat, or common cold symptoms, Hair loss, Itching or rash.

The above information comes from the Internet. Please consult with a doctor for medical advice.

FAQ:

FAQ about (URSODEOXYCHOLIC ACID)/ Actigall Generic URSODEOXYCHOLIC ACID:

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URSODEOXYCHOLIC ACID has different brand names depending on the manufacturer. Some of the brand names are: